Synthesis and characterization of a nanocomposite based on bioactive glasses containing superparamagnetic iron oxide nanoparticles aiming bone tumor treatment

Reference	Presenter	Authors (Institution)	Abstract
02-091	Roger Borges	Borges, R.(Federal University of Abc); Lourenço, I.M.(Federal University of ABC); Seabra, A.B.(Federal University of Abc); Ferreira, L.M.(Federal University of ABC); Rettori, C.(Federal University of ABC); Marchi, J.(Federal University of Abc);	A successful treatment of bone tumor should ally an effective treatment of cancer and bone regeneration. Magnetite nanoparticles are standard materials for hyperthermia applications due to their superparamagnetic behavior, while bioactive glasses are outstanding biomaterials for bone regeneration. In this sense, we studied the structure and magnetic properties of a novel nanocomposite made out of superparamagnetic iron oxide nanoparticles embedded in bioactive glass aiming to obtain an osteoinductive and superparamagnetic biomaterial suitable for bone tumor treatment. The magnetite nanoparticles were obtained through thermal decomposition method, and the bioactive glass containing the magnetic nanoparticles (10, 20 and 30 wt.%) were obtained by quick alkali sol-gel method. The structure of the nanocomposite was characterized by X-ray diffraction and X-ray photoemission spectroscopy, and the morphology by field emission gun scanning electron microscopy (FEG-SEM). Magnetic characterization was obtained in a VSM-SQUID magnetometer by means of zero-field-cooled (ZFC), field-cooled (FC) and field dependent magnetization measurements. Our results showed that particles of ~150 nm were obtained, exhibiting a major part of an amorphous glass material containing magnetite as secondary crystalline phase. The addition of iron nanoparticles to the glass structure led to an increase in network connectivity, indicating a possible diffusion of iron oxide into the glass structure. The magnetic characterization confirmed the superparamagnetic behavior of these nanocomposites. These results suggest that bioactive glasses containing superparamagnetic iron oxide nanoaparticles may be promising materials for treatment of bone tumor by allying the hyperthermia and bone regeneration properties.
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