Cobalt therapeutic ion incorporated into the hybrid scaffold polyvinyl alcohol (PVA) / bioactive glass (BG) and its implications in angiogênesis

Reference	Presenter	Authors (Institution)	Abstract
03-028	Andréia Grossi S Laia	Laia, A.G.(Universidade Federal de Minas Gerais); de Sá, M.A.(Universidade Federal de Minas Gerais); Valverde, T.M.(Universidade Federal de Minas Gerais); Barrioni, B.R.(Universidade Federal de Minas Gerais); Pereira, M.d.(Universidade Federal de Minas Gerais);	Bioactive glasses (BGs) are promising mainly for the repair of bone tissues due to their high bioactivity and biocompatibility. BGs have variable and highly flexible composition, allowing the incorporation of metallic ions with therapeutic effect, a propitious approach in the development of BGs with superior properties for tissue engineering. These ions have the advantage of being released exactly at the implant site, optimizing the therapeutic effect and reducing side effects in the patient as they are released in a controlled manner during the process of material degradation. The cobalt ion (Co) presents great potential for incorporation into the structure of bioactive glasses, since it may influence the formation of new blood vessels from the stabilization of the hypoxia induction factor (HIF), known to activate genes related to angiogenesis. Thus, the main objective of this work was to synthesize hybrid scaffolds with Polyvinyl Alcohol (PVA) and new bioactive glass compositions (BG) based on the SiO2-CaO-P2O5-CoO system, through the sol-gel method, and to investigate the effects of Co incorporation on their structure. Porous three-dimensional scaffolds based on PVA and BG containing Co were prepared and characterized by MicroCT, FTIR, XRD, SEM and ICP-OES to verify the chemical composition and structural characteristics. The scaffolds must have pore porosity and interconnectivity to allow cell growth, adequate biocompatibility and acceptable ionic release to promote support during the time required for new tissue growth. Microporous composites containing a bioactive phase and a resorbable polymer phase are promising in tissue engineering where the ceramic phase can be added to improve or introduce osteogenic and angiogenic properties by constructing a material with superior properties and potential use for tissue engineering.
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