Evaluation of bioactive glass effect on fluid handling capacity of novel 3D composites of chitosan/bioactive glass for wound dressing applications
| Reference | Presenter | Authors (Institution) | Abstract |
|---|---|---|---|
| 03-027 | TALITA MARTINS | MARTINS, T.(Universidade Federal de Minas Gerais); Costa Júnior, E.d.(Centro Federal de Educação Tecnológica de Minas Gerais); Pereira, M.d.(Universidade Federal de Minas Gerais); | The skin lesions have great importance due to the various functions of this tissue. Under normal circumstances, the wound healing progresses in an orderly manner. However, alterations such as dermatologic proliferative disorders can occur. Due to these factors, there is a necessity for the development of topical coverage that allows the reepithelialization of the injured site in an orderly manner, aiding the healing process. These materials should have adequate porosity, appropriate pore size, interconnectivity, and mechanical behavior compatible with the features of native tissue. A promising alternative is the production of flexible 3D composite matrices by the foaming method. In this work, novel flexible 3D composite foams of chitosan (CH)/bioactive glass (BG) (SiO2-CaO-P2O5), in 1:0, 3:1 and 1:1 ratios, were developed using the sol-gel route and a foaming step. In addition to the effects of physical crosslinking expected by the incorporation of bioactive glass, it improved the antimicrobial effect, desired for biomaterials intended for topical application. Physical characterization was performed by SEM and micro-CT to evaluate the porous structure of the samples. Fluid Absorptive Capacity, Water Vapor Transmission, and Fluid Handling Capacity were measured. Our results revealed that CH/BG foams presented a highly porous structure with interconnectivity. The addition of the BG was able to modulate the permeation and water absorption capacity in the foams. These materials may be potential alternative scaffolds for wound dressings applied in tissue regeneration and healing stimulation. The authors gratefully acknowledge CNPq, FAPEMIG, CAPES for financial support on this project. |
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