Obtaining porous bodies of hydroxyapatite and beta tricalcium phosphate using gelatin

Reference	Presenter	Authors (Institution)	Abstract
02-030	Eliana Cristina Da Silva Rigo	Rigo, E.C.(Universidade de São Paulo, Campus Pirassununga); Conti, G.T.(Universidade de São Paulo, Campus Pirassununga); Vercik, L.C.(Universidade de São Paulo, Campus Pirassununga); Vercik, A.(Universidade de São Paulo, Campus Pirassununga);	Porous ceramic bodies, used for bone substitution due to their biocompatibility, must have pore sizes that allow colonization, migration and adhesion of bone cells (osteoblasts and osteoclasts), as well as microporosity and interconnected paths allowing the diffusion of nutrients and gases during the regeneration process. Thus, the present work addressed the production of porous bodies of hydroxyapatite (HA) and beta tricalcium phosphate (B-TCP) using gelatin solution by the replica method. Bodies were obtained by two different routes: 1) by chemical precipitation of HA and B-TCP powders added subsequently in solutions containing 8% gelatin (w/v) where polyurethane sponges were immersed; 2) use of gelatin 8% (w/v) during the precipitation process of the HA and B-TCP powders and subsequent completion of each precipitation, followed by the immersion of polyurethane sponges in these solutions. The samples were dried for 24h at 30°C and sintered at 1300°C. The starting powders were characterized by analysis of particle size distribution, X-ray diffraction (XRD) and scanning electron microscopy (SEM). The porous bodies were characterized by XRD and SEM. The particle size distribution analysis of the powders obtained by methodology 1 yielded a mean diameter of 5.3?m for HA and 100nm for B-TCP. The SEM analysis of the porous bodies showed macro porosity with mean size of 0.3mm for HA and 0.6mm for B-TCP. The porous bodies obtained by methodology 2 exhibited pores of about 1.0 mm for HA, whereas this analysis was not possible for the B-TCP. The results demonstrates the viability of both processes, using a gelatin solution in the precipitation step as well as in the preparation of the solution of the starting powders.
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