7th International Congress on Ceramics

IN VITRO BIOACTIVITY TESTS IN A COMPOSITE BASED ON MAGNETITE, POLYVINYLIDENE FLUORIDE AND CALCIUM PHOSPHATE USING SIMULATED BODY FLUID (SBF)

Reference	Presenter	Authors (Institution)	Abstract
03-010	Milena Schroeder Malherbi	Malherbi, M.S.(Universidade Estadual do Centro-Oeste); Silva, L.M.(Universidade Estadual de Maringá); Bini, R.D.(Universidade Estadual de Maringá); Rosso, J.M.(Universidade Estadual de Maringá); Santos, I.A.(Maringa State University); Freitas, V.F.(Universidade Estadual do Centro-Oeste); Bonadio, T.G.(Universidade Estadual do Centro-Oeste);	Many artificial materials when implanted into bone defects are encapsulated by a fibrous tissue, leading to their isolation from the surrounding bone. However, there are materials called bioactive that establish a direct bond with the bone. In this case, an apatite layer appears on the surface of the material when it is implanted in vivo. Interestingly, in vivo bone bioactivity of a material may be predicted from apatite formation in vitro in a simulated body fluid (SBF) [1, 2]. In this study, it was evaluated the in vitro bioactivity of piezoelectric composites based on polyvinylidene fluoride, calcium phosphate and magnetite (PVDF-HA- ${Fe}_{3} O_{4}$ ). Some samples were submitted to the application of an alternating magnetic field of 8 Oe and 1 kHz of frequency. After the tests, the composites were characterized by analysis of scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The results showed that composites exhibited formation of apatite on their surfaces, being able to considered bioactive. Furthermore, in the samples that the magnetic field was applied, the formation of apatite occurred in a shorter time. Therefore, the use of an alternating magnetic field and implants that are simultaneously bioactive, magnetic and piezoelectric may accelerate the process of apatite growth in vitro. This work may motivate future researches using multifunctional materials and magnetic stimuli to catalyze the bone growth in orthopedic treatments. [1] T. Kokubo, H. Takadama, “How useful is SBF in predicting in vivo bone bioactivity?” Biomaterials 27 (2006) 2907 [2] A. L. Andrade, R. Z. Domingues, “Cerâmicas Bioativas – Estado da Arte”, Química Nova, Vol. 29, 2006.
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