SYNTHESIS AND CHARACTERIZATION OF HYBRID MATERIALS BASED ON MESOSPOROUS SILICA MCM-41 AND RESPONSIVE HYDROGELS AS DEVICES FOR CONTROLLED DRUG RELEASE

Reference	Presenter	Authors (Institution)	Abstract
02-021	Tatiane dos Santos Lisboa	Lisboa, T.d.(Centro de Desenvolvimento da Tecnologia Nuclear); Sousa, E.M.(Centro de Desenvolvimento da Tecnologia Nuclear); Sousa, R.G.(Universidade Federal de Minas Gerais);	The discovery of mesoporous materials is a recent breakthrough in materials science and engineering. Mesoporous silica is a promising material for controlled drug delivery systems (DDS) due to its high mechanical and thermal stability, large surface area and large pore volume. This material becomes even more interesting when it is combined with externally stimuli-responsive hydrogels, optimizing its adsorption capacity and drug release control. Responsive hydrogels provide drug release in specific areas at controlled rates due to their ability to swell and contract as a response to external environment changes. The present study seeks to combine mesoporous silica and a thermo and pH-sensitive copolymer creating a highly target-specific DDS as a new perspective for pharmaceutical industry. Delivery drug systems containing different concentrations of the copolymer poly [(N-isopropylacrylamide) -co- (methacrylic acid)] - P [(N-iPAAm) -co- (MAA)] and mesoporous silica MCM-41 were synthesized. The materials were characterized by thermogravimetric analysis (TGA), CHN elemental analysis, Fourier-transform infrared spectroscopy (FTIR), small-angle X-ray scattering (SAXS), N2 adsorption, Zeta potential, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and differential scanning calorimetry (DSC) for evaluation of their physical-chemical properties. Chemical bonds were identified and the chemical elements (CHN) present in the nanohybrid were measured. Both results indicate the presence of hydrogel inside the mesoporous silica structure. Stability tests were carried on, in order to verify the strength of the bonds between the phases present in the nanohybrid. The results confirm the success of the synthesis of the nanohybrid systems, and stimulate the investigation of these materials as carriers for antitumor drugs.
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