Gold nanorods coated by mesoporous silica for application in hyperthermia
| Reference | Presenter | Authors (Institution) | Abstract |
|---|---|---|---|
| 02-014 | Lucas Bessa Lopes | Lopes, L.B.(Centro de Desenvolvimento da Tecnologia Nuclear); Sousa, E.M.(Centro de Desenvolvimento da Tecnologia Nuclear); | Gold nanoparticles have been well studied due to a range of applications that are available. Gold nanorods are nanoparticles where its diameter is smaller than its length conferring it the format of a stick. This characteristic shape presents interesting properties, optical and thermal properties, such as the conversion of the energy coming from an electromagnetic radiation in the near infrared region (NIR) into thermal energy. In this case, tumors treatment is an important bio application by local hyperthermia, which means int’s possible to break up and kill tumor cells by increasing temperature over 5 °C in the desired region. Overheating caused by the incidence of NIR radiation in the gold nanorods can result in the loss of the characteristic shape of the nanorod, thus losing the ability to generate heat. For the protection of the nanorods, a solution was used to coat them with a thin layer of mesoporous silica. It consists of spherical nanoparticles with pores in the order of 2-10 nm consisting of silica and oxygen chains giving them specific characteristics, such as large surface area and high thermal resistance. In this context, the objective of this work was the production of nanostructured systems based on silica and gold nanorods for applications under local hyperthermic conditions. The synthesis of nanorods is based on the seed-mediated method followed by the incorporation of silica on the surface thereof. .The characterization of the formed nanostructure will be performed by UV-Vis, zeta potential, FTIR, BET, SEM and TEM. The results indicate that the nanocomposites synthesized in this work have great potential of application in the biomedical area. Sadeghi, B. Synthesis and Application of Nanorods. Nanorods, cap 6, p. 117-128. 2012. Huff, T. B. et. al., Hyperthermic effects of gold nanorods on tumor cells. Nanomedicine. vol. 2(1): p. 125–132. 2007. |
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